Clarence Seedorf began his professional career with Dutch Eredivisie giants Ajax Amsterdam as a teenager and he was one of many young players in the Ajax team that saw off a more experienced AC Milan side in the 1995 Champions League final to win the competition under the guidance of Dutchman Louis Van Gaal.

Patrick Kluivert was the hero for Ajax Amsterdam as he scored late in the game to propel Ajax Amsterdam to a 1-0 win in the final at the expense of an AC Milan side who came into the game as defending champions. Milan became the Champions League holders thanks to the thumping 4-0 win over a star-studded Barcelona side during the 1994 Champions League final. In the 1995 Champions League final, Nigerian striker Kanu Nwankwo came on for Clarence Seedorf on 53 minutes and he was one of the main catalyst for the win.

Apart from the 1994/95 Champions League title, Clarence Seedorf also won two Dutch Eredivisie titles, one Dutch Super Cup title and one Dutch Cup title during his time at Ajax Amsterdam. He was in the Ajax Amsterdam first team squad for a period of three years from 1992 to 1995.

Clarence Seedorf won his second major trophy with Ajax Amsterdam in the 2003 Dutch Super Cup which ended in a 4-0 win for his team. Ajax Amsterdam blew Feyenoord away with a brace from Finnish striker Jari Litmanen either side of the interval in addition to second half goals from Frank De Boer and Marc Overmars. Litmanen scored the first and the last goal of the game, while De Boer and Overmars were responsible for the second and third goals respectively.

Seedorf won his first major trophy at Ajax Amsterdam with the 1992/93 Dutch Cup title. Ajax thumped Heerenveen 6-2 in the final to win the Dutch Cup.